This is the second installment of an infamous trilogy of movies directed by Kazuo Komizu (GUTS OF A VIRGIN AKA ENTRAILS OF A VIRGIN, GUTS OF A BEAUTY AKA GUTS OF A VIRGIN 2, and GUTS OF A VIRGIN 3 AKA FEMALE INQUISITOR). The films are not true sequels to one another and have little in common besides their Yakuza characters and extreme sexual violence and gore.

In this film, a young woman named Yoshimi (Seira Kitagawa) is abducted by her boyfriend Higashi, a petty Yakuza thug who intends to dope her up and sell her into prostitution in Africa through the Ichiyama clan- her sister Keiko already met the same fate.  However, after Yoshimi is brutally raped by five Yakuza members, the two thugs left to guard her pass out from their own drug abuse, allowing her to escape.  Yoshimi makes it to a hospital and tells the female psychiatrist there, Hiromi (Megumi Ozawa), her whole story.  Unfortunately, the drugs kick in and she freaks out, jumping off the hospital roof to her death on the street below.

Hiromi decides to get vengeance for the dead woman and her sister, and so she lurks in the bar favored by the local Yakuza and seduces Higashi and hypnotizes him, causing him to freak out and attack his fellow gangsters in a psychotic rage.  Before he is killed and his corpse is chopped into sashimi, the boss, Yoshioka (Ken Yoshizawa), gets enough information out of him to know that there is a female avenger gunning for all of them.  It does not take him long to identify Hiromi as the culprit, and she too is drugged, gang-raped, and murdered.